GSKIP (GSK3-beta interaction protein)

The A-kinase anchoring protein (AKAP) glycogen synthase kinase 3{beta} interaction protein (GSKIP) regulates {beta}-catenin through its interactions with both protein kinase A (PKA) and GSK3{beta}

This research was originally published in Journal of Biological Chemistry. Dema, A. and Schroeter, M.F. and Perets, E. and Skroblin, P. and Moutty, M.C. and Deak, V.A. and Birchmeier, W. and Klussmann, E. The A-kinase anchoring protein (AKAP) glycogen synthase kinase 3{beta} interaction protein (GSKIP) regulates {beta}-catenin through its interactions with both protein kinase A (PKA) and GSK3{b...

Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus.

Estrogens regulate a wide set of neuronal functions such as gene expression, survival and differentiation in a manner not very different from that exerted by neurotrophins or by growth factors. The best-studied hormonal action is the transcriptional activation mediated by estrogen receptors. However, the direct effects of estrogen on growth factor signaling have not been well clarified. The pre...

Repository of the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association http://edoc.mdc-berlin.de/15203 The A-kinase anchoring protein GSKIP regulates GSK3{beta} activity and controls palatal shelf fusion in mice

Prediction of Protein Sub-Mitochondria Locations Using Protein Interaction Networks

Background: Prediction of the protein localization is among the most important issues in the bioinformatics that is used for the prediction of the proteins in the cells and organelles such as mitochondria. In this study, several machine learning algorithms are applied for the prediction of the intracellular protein locations. These algorithms use the features extracted from pro...

Phosphorylation of NBR1 by GSK3 modulates protein aggregation

The autophagy receptor NBR1 (neighbor of BRCA1 gene 1) binds UB/ubiquitin and the autophagosome-conjugated MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3) proteins, thereby ensuring ubiquitinated protein degradation. Numerous neurodegenerative and neuromuscular diseases are associated with inappropriate aggregation of ubiquitinated proteins and GSK3 (glycogen synthase kinase 3) act...